Given its increasing incidence and serious complications, osteoporosis requires safe and effective long-term treatment. Strontium ranelate (SR), a new anti-osteoporotic treatment with a unique mode of action, has been investigated in the SOTI (Spinal Osteoporosis Therapeutic Intervention) and the TROPOS (Treatment of Peripheral Osteoporosis) …

In 1959, Mayo Clinic researchers reported significant improvement in severe osteoporosis, and in 1986, a pioneer in late-20th-century strontium research published microscopic observations about how strontium works to improve bone building and bone density. After 1986, very little research on strontium was done or reported until just a few years ...

Strontium ranelate has been traditionally utilized to treat osteoporosis because it releases Sr ions, which directly prevent osteoclast activation and promote …

Strontium ranelate is an anti-osteoporosis drug with a unique mechanism of action (used primarily in postmenopausal women). Unlike other medicines, it has a multidirectional effect on bone tissue, intensifying osteoblastogenesis while inhibiting osteoclastogenesis. It turns out that this effect is demonstrated by strontium ions, an …

A. Strontium (Sr) is a chemical element found in water and food. When taken orally, it's absorbed in the body in small amounts, mainly in areas where bone is being remodeled — that is, undergoing the natural process by which it is broken down and formed. The word "strontium" may make some people think of strontium-90, a …

Results from a two-year placebo-controlled, phase 2, dose–response study involving 353 postmenopausal women with …

Strontium and Osteoporosis: A treatment not offered to American women. 2. Dean, W. (May 5 2004). Strontium: Breakthrough against Osteoporosis. 3. Wright, J.V. Fight—even prevent osteoporosis with the hidden secrets of this bone-building miracle mineral. (Reprinted from Nutrition and Healing). 4.

The novelty of strontium ranelate compared to other treatments for osteoporosis is its unique effect on bone: it simultaneously promotes bone formation by osteoblasts and …

Strontium ranelate is a new treatment for osteoporosis therefore, its benefits and harms need to be known. Objectives. To determine the efficacy and safety of …

The nutrients strontium and vitamin K2 are effective additions to calcium and vitamin D supplementation for the prevention and treatment of osteoporosis. Any nontoxic strontium salt (not radioactive strontium-90) can strengthen bone, according to …

Another remarkable benefit of strontium supplementation is pain relief and remineralization in bones affected by cancer metastasis, something that occurs with advanced breast or prostate cancer. Strontium supplements also reduce the incidence of dental cavities and improve cartilage metabolism in osteoarthritis.

Strontium ranelate is therefore an important alternative in today's management of osteoporosis, with a positive benefit-risk balance, provided that the …

Abstract. (1) Strontium ranelate is marketed in the European Union for the treatment of postmenopausal osteoporosis. Strontium, a cation closely related to calcium, was already used for this purpose in the 1950s but was abandoned because it caused bone mineralization disorders (mainly due to the high doses used at the time).

Osteoporosis is a chronic disease characterized by low bone mass caused by increased bone turnover and impaired bone microarchitecture. In treatment, we use antiresorptive or anabolic drugs, which usually have a unidirectional effect, i.e., they inhibit the activity of osteoclasts or stimulate the effect of osteoblasts. Strontium ranelate is an …

For more information see Strontium breakthrough against osteoporosis where references to all the above studies can be found, as below - References. McCaslin, F.E., Jr., and Janes, J.M. The effect of strontium lactate in the treatment of osteoporosis. Proc Staff Meetings Mayo Clin, 1959, 34:329-334.

Strontium, acting through the CaSR receptor on osteoblasts, increases production of osteoprotegerin and reduces expression of RANKL mRNA, which prevents the binding of RANKL to RANK, leading to the inhibition of …

The successful treatment of osteoporosis is a relatively recent phenomenon.Although bisphosphonates are now established as the treatment of choice, 1 this only came about with the publication in 1996 of the FIT alendronate trial. 2 Nowadays the main treatment options are anti-resorptive agents that prevent bone breakdown. …

Strontium ranelate is an anti-osteoporosis drug with a unique mechanism of action (used primarily in postmenopausal women). Unlike other medicines, it has a …

The drug makes your bones stronger and lowers your chances of getting fractures. Doctors aren't sure exactly how it works, but it seems to help the body make more bone and keep the bone you have ...

2 min read. If you are concerned about the bone-thinning disease osteoporosis, you may have heard about treatment with strontium. Some people say …

PREVOS and STRATOS research. The PREVOS and STRATOS research was conducted to determine a minimum effective dose for strontium. The studies showed the "minimum dose at which SR is effective in preventing bone loss in early postmenopausal nonosteoporotic women and in the treatment of postmenopausal …

I have been treated with bisphosphanates, forteo, prolia and I had 11 non-traumatic spontaneous vertebral compression fractures during treatment. I now take 680 mg strontium citrate without side effects and the fractures have stopped. Do not take it within 2 hours of ingesting calcium -- so I take it at bedtime.

Subsequently, strontium was used therapeutically in the United States and Europe. As late as 1955, strontium compounds were still listed in the Dispensatory of the United States of America. For decades in the first half of the twentieth century, strontium salts were administered in dosages of 200 to 400 mg/day without toxic effects."

Strontium and Osteoporosis: A treatment not offered to American Women Dean, W. (May 2004) Strontium breakthrough against Osteoporosis. Know someone who might benefit from this article? Share it! 2 …

Strontium: Breakthrough Against Osteoporosis [PDF] Related documentation Guidelines on Management of Osteoporosis, April 2011 (Updated 04/2012, 06/2013, 09/2013, 04/2014, 09/2014 and 02/2015)

For weak and brittle bones (osteoporosis): 0.5-2 grams of strontium ranelate has been taken daily for up to 10 years. The highest dose of 2 grams daily seems to work the best. For ostearthritis: 1 ...

Strontium: Breakthrough Against Osteoporosis by Ward Dean, MD Mention strontium to most people, and they will almost always immediately think of strontium-90, a highly dangerous, radioactive component of nuclear fallout produced during atmospheric testing of nuclear weapons in the 1950s. As a result of above-ground nuclear testing, radioactive …