Copper is an essential element required for normal human metabolism. Studies indicated that serum Copper deficiency in pregnant women can have been associated with some adverse effects such as Premature Rupture of Membrane (PROM), abortion, fetus growth restriction etc . Zinc (Zn) is essential for cell growth, development …

In epidemiological studies, serum copper levels in patients with osteoporosis, lumbar osteopenia and femoral neck fracture were lower than those in the normal group, and low serum copper levels were also considered as a risk factor for age-related osteoporosis. Some even suggested that copper could be used as a simple …

Background: Several studies have shown that serum copper levels are related to coronary heart disease, diabetes, and cancer. However, the association of serum copper levels with all-cause, causespecific (including cardiovascular disease [CVD] and cancer) mortality remains unclear.Objectives: This study aimed to prospectively examine …

Published: 01 November 2023. Association of serum copper (Cu) with cardiovascular mortality and all-cause mortality in a general population: a prospective cohort study. …

Objective: To compare the serum levels of copper (Cu), zinc (Zn), selenium (Se) and copper/zinc ratio in women with unexplained infertility and fertile women. Subjects and methods: This was a cross-sectional analytical study that compared 75 consenting women who had unexplained infertility with 74 fertile women that were controls. Both groups ...

Excessive serum copper has multiple effects on human health, while the association between copper and obesity remains unclear. The objective of this study is to examine the associations of serum copper concentrations with obesity and adiposity measures, including body fat composition and distribution among adults in the USA. This …

The serum copper distribution was depicted using the histogram. Adjusted hazard ratios (95% CI) for CVD and all-cause mortality are shown with red curves. The serum copper level considered for this analysis was 18.1 µmol/L. The model cubic spline curves have 3 knots. Adjustments included age, , marital, education, BMI, eGFR, …

Purpose Serum copper (Cu), zinc (Zn), and Cu/Zn-ratio have emerged as ageing-related biomarkers. We sought to assess the association between Cu/Zn-ratio and chronic obstructive pulmonary disease (COPD) risk. Methods Serum Cu and Zn were measured using atomic absorption spectrometry in 2,503 men aged 42–61 years. …

The role of serum copper as a putative risk factor for CVDs requires further exploration. The exact mechanisms underlying the association between elevated serum copper …

Article. Published: 29 July 2022. Nutrition in acute and chronic diseases. Relationship of serum copper and zinc with kidney function and urinary albumin to creatinine ratio: …

Copper is essential for various biological processes. However, excess copper has several adverse health effects. The effects of serum copper on muscle mass are poorly understood. This study aimed to investigate the association between serum copper levels and muscle mass in the US population. We utilized National Health and …

Among the levels of serum copper, selenium, and zinc, only the association between depression symptoms and serum copper levels was observed to be significant in the unadjusted model (P = 0.002). Individuals with a high copper level (114–134 μg/dL) and a very high copper level (≥ 134 μg/dL) had 1.85 (95% CI 1.24, 2.77)- and 1.72 (95% CI 1. ...

ORIGINAL RESEARCH article. Front. Cardiovasc. Med. Sec. Cardiovascular Epidemiology and Prevention. Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1340968. High …

Abstract. Background and Objective: Serum copper has been linked to the risk of atherosclerotic cardiovascular disease (CVD). However, the potential association between serum copper and venous thromboembolism (VTE) is not known. The principal aim was to evaluate the potential prospective association between serum copper and …

Twenty-six articles were included in the meta-analysis. The increase in Cu level exponentially decreased in COC users over time, with a rapid decline through the 1960s and 1970s. After controlling for the publication year, use of COC increases the mean serum/plasma Cu level by 0.57 mg/L (95% confidence interval 0.49 0.66 mg/L).

Alternate biomarkers of copper, such as platelet copper, erythrocyte copper, and erythrocyte superoxide dismutase, have all been shown to be as unreliable as serum copper and are not routinely used in assessing copper deficiency [3,4]. The gold standard for the assessment of total body copper is liver biopsy with staining but its …

Serum ceruloplasmin is also a valuable test and can be used to determine the free serum copper. Copper reference ranges are as follows: Free serum copper: 1.6-2.4 μmol/L or …

Ask your healthcare provider what your test results mean for you. The normal range for total copper in the blood is 62 to 140 micrograms per deciliter (mcg/dL). A low amount of copper could mean that you have: Kidney disease. A nutritional deficiency. Inability …

Staging of Wilson Disease. Stage 1: initial accumulation of copper in the liver. Stage 2: Acute redistribution of copper within the liver, followed by release into the systemic circulation. Stage 3: Chronic accumulation of copper into extrahepatic tissues including brain. Stage 4: Use of chelation therapy to restore copper balance.

Eleven studies suggested that serum copper levels are higher in patients with cervical cancer compared with that in controls, while one article had reported the lack of significant association. However, two publications [ 20, 21 ] indicated that it was significantly lower in patients with cervical cancer relative to controls about serum copper ...

The occurrence of non-alcoholic fatty liver disease (NAFLD) is globally increasing. To challenge the current incidence of NAFLD, non-invasive markers that could identify patients at risk or monitor disease progression are an important need. Copper intake and organ copper concentrations have earlier been linked to NAFLD progression, …

Serum copper (Cu) and zinc (Zn), essential micronutrients that have important immunomodulatory and antimicrobial properties, are biomarkers of ageing. Serum Cu/Zn-ratio may be a more reliable marker for age-related degenerative conditions compared with serum Cu or Zn alone. We aimed to assess the association between Cu/Zn-ratio and the …

Background Copper (Cu) homeostasis and Cu-induced cell death are gaining recognition as crucial processes in the pathogenesis of cardiovascular disease (CVD). Circulating Cu associated with CVD and mortality is yet to be fully elucidated. Objective This national prospective cohort study is to estimate relationship between serum Cu and the …

Serum copper to zinc ratio: Relationship with aging and health status - ScienceDirect. Mechanisms of Ageing and Development. Volume 151, November 2015, …

The serum concentrations of zinc and copper appear to be less sensitive to nutritional changes except during periods of severe deficiency or supplementation .This indicated that most AML patients were under a severe condition of Zn deficiency in the circulation, although this was not associated with the clinical outcomes of AML patients.

High serum copper might be related to the development of the pathological lesions observed in RA and not just be a secondary response. Full text Get a printable copy (PDF file) of the complete article (536K), or click on a page image below to browse page by page.

Skalny et al., 2021 also observed that increasing COVID-19 severity is associated with a significant gradual decrease in serum Zn levels (together with decreased serum levels of calcium, iron and selenium) when compared with controls. However, serum Cu and especially the Cu:Zn ratio are increased . Increased Cu:Zn ratio has been used …

Then, 42 articles were excluded because of not being the serum sample (9 in whole blood, 6 in plasma, 13 in toenail or hair, and 14 in tissue). Further, 11 articles (4 with duplicated data, 5 lacked of available data, and 2 with abnormal high levels of Zn) were excluded. Finally, a total of 36 studies available. serum copper and breast cancer

When serum copper was estimated as a categorical variable, subjects with levels in the highest tertile (T3, >19.8 µmol/l), but not the middle tertile (T2, 16.4-19.8 µmol/l), had an increased prevalence of stroke compared to those with levels in the lowest tertile (T1, <16.4 µmol/l) in crude logistic regression (T3: ...

The serum copper concentration was quantified using inductively coupled plasma dynamic reaction cell mass spectrometry (ICP-DRC-MS), a powerful multielement analytical technique with the ability to detect even trace levels of elements. All the data exceeded the lower limit of detection (LLOD) for the tests. The LLOD of serum copper …